学术资讯
精选来自 arXiv、SSRN、bioRxiv 等主流预印本平台的最新学术资讯，均转载自原平台公开信息，非本站投稿，不代表本站已收录或已授予 DOI，点击「阅读原文」查看完整内容。
An Evidence-Graded Framework for Pharmaceutical Route Selection and Process-Risk Prioritization: A PN6047 Case Study
基于证据分级的药物路线选择与工艺风险优先级排序框架：以PN6047为例
Leon Sandler
Purpose: To develop and demonstrate an evidence-graded framework for screening discovery-scale synthetic routes before experimental process development, using the publicly disclosed route to PN6047, a clinical-stage δ-op…
2026-10-09 · DOI: 10.26434/chemrxiv.15010156/v1 · 阅读原文 →
Mutual-friction self-focusing of a Hasimoto soliton and its torsion-driven arrest: a conserved amplitude–torsion pairing on a superfluid vortex filament
Hasimoto孤子的互摩擦自聚焦及其扭转驱动的阻挫：超流涡丝上守恒的振幅–扭转配对
Andrei T. Patrascu
Abstract A quantized vortex in superfluid helium-4 moves under its self-induced velocity and, at finite temperature, under mutual friction with the normal fluid. In the local-induction approximation the frictionless fila…
2026-10-09 · DOI: 10.21203/rs.3.rs-11143886/v1 · 阅读原文 →
Land use and climate warming interact to reshape global avian biodiversity through ecological filtering and homogenisation
土地利用与气候变暖通过生态过滤和同质化共同重塑全球鸟类生物多样性
Chenchen Ding, Tim Newbold, Adrienne Etard, Richard Cornford 等
Land-use and climate change are dominant drivers of terrestrial biodiversity change, yet are usually analysed separately although they co-occur and may interact. We integrated global bird assemblage records from PREDICTS…
2026-10-09 · DOI: 10.64898/2026.10.08.757631 · 阅读原文 →
Reconciling intrinsic and ecosystem water-use efficiency reveals physiological mechanisms underlying carbon-water coupling across biological scales
协调内在与生态系统水分利用效率揭示跨生物尺度碳-水耦合的生理机制
Paulina F. Puchi, Daniela Dalmonech, Daniele Castagneri, Elia Vangi 等
Understanding how carbon-water coupling scales from leaves to ecosystems remains a major challenge because water-use efficiency (WUE) metrics integrate physiological, hydrological, and ecological processes. We integrated…
2026-10-08 · DOI: 10.64898/2026.10.07.757244 · 阅读原文 →
Sex-dependent DNA methylation in amyotrophic lateral sclerosis
肌萎缩侧索硬化中性别依赖的DNA甲基化
Young Jun Kim, Alfredo Iacoangeli, Ramona A.J. Zwamborn, Wouter van Rheenen 等
Amyotrophic lateral sclerosis (ALS) shows well-established sex differences in incidence, age at onset and progression, but their biological basis is unclear. We hypothesised that the DNA methylation changes associated wi…
2026-10-08 · DOI: 10.64898/2026.09.30.755680 · 阅读原文 →
Damage–repair kinetics and phase stiffness in a site-diluted XY model: implications for irradiated superconductors
位点稀释XY模型中的损伤-修复动力学与相刚度：对辐照超导体的启示
Leon Sandler
Neutron damage lowers the transition temperature of REBCO conductors approximately linearly with displacement damage, and annealing recovers part of it, implicating phase stiffness. We model this competition as a two-dim…
2026-10-08 · DOI: 10.26434/chemrxiv.15010100/v1 · 阅读原文 →
The ARumenamide AR-788 suppresses the transient outward current in human iPSC-derived right-ventricular Brugada cardioids
ARumenamide AR-788抑制人iPSC来源的右心室Brugada心脏类器官中的瞬时外向电流
Yohan Gueret, Aurore Girardeau, Sarah Godin, Maureen Choteau‐Bodor 等
Abstract Brugada syndrome (BrS) is an inherited arrhythmia disorder with limited drug therapy, quinidine being the principal agent. Loss-of-function variants in SCN5A reduce the cardiac sodium current (INa), but the arrh…
2026-10-08 · DOI: 10.64898/2026.10.06.26364857 · 阅读原文 →
A ribosomal pseudouridine drives an oncogenic translation program
核糖体假尿苷驱动致癌翻译程序
Laurence Faucher‐Giguère, Andrew Rivera, Baudouin S de Préval, Étienne Fafard-Couture 等
Dynamic ribosome heterogeneity has emerged as a potential layer of translational regulation, but whether variation in ribosomal RNA (rRNA) modification stoichiometry can selectively control the translation of mRNAs with …
2026-10-07 · DOI: 10.64898/2026.10.06.757013 · 阅读原文 →
Optimized Efficiency to Minimize Transmission Losses and Reduce Overall System Operating Costs of 1100 kV Converter Transformers for Power Transmission System
优化效率以最小化输电损耗并降低电力传输系统1100 kV换流变压器整体系统运行成本
Mohammad Ali
Abstract Converter transformers are the largest single source of controllable loss in a line-commutated ultra-high-voltage direct-current (UHVDC) converter station, yet they are usually specified with loss-capitalization…
2026-10-07 · DOI: 10.21203/rs.3.rs-11274366/v1 · 阅读原文 →
A map of RBP-miRNA regulatory connections for deciphering the mechanisms of transcriptome remodeling in cancer
RBP-miRNA调控连接图谱用于解析癌症转录组重塑机制
Gabrielle Perron, Mohan Amaravadi, Cynthia Tseng, Pouria Jandaghi 等
Micro-RNAs (miRNAs) are key post-transcriptional regulators of gene expression that influence cancer progression and outcome. Whereas transcriptional dysregulation of miRNA abundance underlies abnormal functionality of s…
2026-10-06 · DOI: 10.64898/2026.09.29.755492 · 阅读原文 →
Search for Higgs boson compositeness effects in high-mass dilepton final states in proton-proton collisions at $\sqrt{s}$ = 13 and 13.6 TeV
在质子-质子碰撞中寻找高质量双轻子末态的希格斯玻色子复合效应，$\sqrt{s}$ = 13 和 13.6 TeV
CMS Collaboration
A search for beyond the standard model effects in high-mass dielectron and dimuon final states with the CMS detector is performed, with a specific focus on Higgs boson compositeness. The search uses data collected at the…
2026-10-06 · DOI: 10.17182/hepdata.180840 · 阅读原文 →
Toward transparent rigid packaging from sugarcane bagasse: a consistency-testing framework for nanocellulose–chitosan sheets
迈向甘蔗渣透明硬质包装：纳米纤维素–壳聚糖片材的一致性测试框架
Leon Sandler
Transparent rigid packaging is dominated by fossil-derived polymers, whereas fiber-based packaging is opaque. Dense cellulose nanofibril (CNF) and nanocrystal sheets are transparent as flat films, but whether transparenc…
2026-10-06 · DOI: 10.26434/chemrxiv.15010009/v1 · 阅读原文 →