学术资讯
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Residue-Conditioned In-Pocket Design for Paralogue Selectivity
残基条件化的口袋内设计用于旁系同源选择性
Ahmed amine Sadouk
Structure based generative model explore chemical spaces inside the protein active site , typically prioritizing candidates through empirical scoring functions.Few evaluate wthether the results is selective for the inten…
2026-09-23 · DOI: 10.26434/chemrxiv.15009331/v1 · 阅读原文 →
Fractal Colonization of Prebiotic Niches: Mechanical Budding of Nano-vesicles and Kinetic Resource Depletion as an Oncological Atavism
分形定植前生命生态位：纳米囊泡的机械出芽与动力学资源耗竭作为肿瘤学返祖现象
Peter Mikuláš
Periodic mechanical forcing of the early Earth, from lunar tides (period of about 10 h) and radiogenic geysers (about 15 min) to von Kármán vortex shedding (about 1 s), may have loaded fatty-acid protocell membranes on…
2026-09-23 · DOI: 10.26434/chemrxiv.15009389/v1 · 阅读原文 →
Blue Technology in Switchgear for Sustainable Power Transmission Systems: Dielectric, Switching, Life-Cycle and Techno-Economic Modelling of SF₆-Free Clean-Air and Vacuum Gas-Insulated Substations
开关设备中的蓝色技术助力可持续电力传输系统：无SF₆洁净空气与真空气体绝缘变电站的介电、开断、生命周期及技术经济建模
Mohammad Ali, Kamrun Nahar, Mohiddin Abdul Quadir, Md Abu Bakkar Siddique
Abstract Sulphur hexafluoride (SF₆) has been the reference insulating and arc-quenching medium of high-voltage switchgear for six decades, but with a global warming potential of about 24 300 and an atmospheric residence …
2026-09-22 · DOI: 10.21203/rs.3.rs-11089340/v1 · 阅读原文 →
Data for "Linear Ensemble-Constrained Quantum Monte Carlo: From Dilute Fermi Gas to Flat-Band Ferromagnetism"
线性系综约束量子蒙特卡洛：从稀薄费米气体到平带铁磁性”的数据
Tu Hong, Kun Chen, Xiao Yan Xu
This dataset contains the numerical data underlying the figures in themanuscript “Linear Ensemble-Constrained Quantum Monte Carlo: From DiluteFermi Gas to Flat-Band Ferromagnetism” by Tu Hong, Kun Chen, and Xiao Yan Xu,i…
2026-09-22 · DOI: 10.5281/zenodo.22891090 · 阅读原文 →
Reproducibility code for "Energy-space quantum walks: Thermalization without state convergence"
能量-空间量子行走：无状态收敛的热化”的可复现代码
Alana Spak dos Santos, R. M. Angelo
This repository provides the reproducibility code for the revised version of the paper "Energy-space quantum walks: Thermalization without state convergence." It contains Python scripts used to reproduce the numerical fi…
2026-09-22 · DOI: 10.5281/zenodo.22897924 · 阅读原文 →
Adjudication at the Worldline: Consolidated Price Discovery Is Physically Undefined; Local Arrival-Order Matching Relocates It, and the Co-location Premium with It
在世界线上的裁决：合并价格发现是物理上未定义的；局部到达顺序匹配将其重新定位，并随之重新定位共置溢价
Paul L. Borrill
The National Best Bid and Offer (NBBO), the consolidated "now" at the centre of U.S. equity market structure under Regulation NMS, requires comparing price events at exchanges whose separation places those events outside…
2026-09-22 · DOI: 10.5281/zenodo.22909943 · 阅读原文 →
Cell-type specific transcriptional risk scores and longitudinal multiple sclerosis outcomes
细胞类型特异性转录风险评分与多发性硬化症纵向结局
Mae Upcott, Beili Shao, Nicholas J. Bray, Sam Loveless 等
Abstract Transcriptional risk scores, an integrated score of genomic susceptibility variants with expression Quantitative Trait Loci (eQTL) data, may more accurately distinguish clinical phenotypes compared to polygenic …
2026-09-22 · DOI: 10.64898/2026.09.21.26363545 · 阅读原文 →
Intelligence by Appointment
约定智能
Brad Pierce
Intelligent systems increasingly have more decision-relevant capabilities and resources than they can use everywhere at once. This paper develops intelligence by appointment as a research program for making the right cap…
2026-09-21 · DOI: 10.5281/zenodo.22882246 · 阅读原文 →
Search for resonant and nonresonant production of pairs of dijet resonances with b jets in the final state in proton-proton collisions at $\sqrt{s}$ = 13 TeV
在质子-质子碰撞中搜索末态含b喷注的双喷注共振态对的共振与非共振产生，$\sqrt{s}$ = 13 TeV
CMS Collaboration
A search is presented for pair-produced dijet resonances of identical mass, each decaying into a bottom (b) quark and a light-flavor quark. The search uses a data sample corresponding to an integrated luminosity of 138 f…
2026-09-21 · DOI: 10.17182/hepdata.169576.v1 · 阅读原文 →
Group-Invariant Certificates and Solvers for Diversity Selection in Combinatorial Libraries
群不变证书与组合库多样性选择的求解器
Anni Yao, Anni Yao
Selection of massive, mutually non-redundant subset of highly scoring compounds from a combinatorial library is a standardized design in early stage drug discovery. It is usually solved by heuristics that return a rankin…
2026-09-21 · DOI: 10.26434/chemrxiv.15009197/v1 · 阅读原文 →
Transient excitability and synaptic consolidation support stable memory despite neural drift
瞬时兴奋性与突触巩固在神经漂移下支持稳定记忆
Surbhit Wagle, Claudia Clopath
Long-term memories remain behaviorally stable despite turnover in the neuronal populations that encode them. This representational drift differs across brain regions: hippocampal representations can reconfigure within ho…
2026-09-21 · DOI: 10.64898/2026.09.15.751773 · 阅读原文 →
Dale's law, stability and nonlinearity are sufficient constraints to ignite transient and self-sustained neural dynamics
Dale定律、稳定性与非线性是激发瞬态及自持神经动力学的充分约束
Nicoleta Condruz, Ivan Bulygin, Chaitanya Chintaluri, Tim P. Vogels
The motor cortex orchestrates a rich and flexible repertoire of network dynamics for rhythmic and goal-directed movements. Computational studies have begun to illuminate the mechanistic origins of this repertoire, but a …
2026-09-21 · DOI: 10.64898/2026.09.14.751508 · 阅读原文 →