学术资讯
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ULK1 and ULK2 Restrain Skeletal Myofiber Growth by Balancing Protein Synthesis and Degradation
ULK1和ULK2通过平衡蛋白质合成与降解抑制骨骼肌纤维生长
Wangkuk Son, Jordan D. Fuqua, Matthew P. Harris, Ryan J. Allen 等
Background Skeletal muscle is vital for mobility and metabolic regulation, impacting independence and overall health. Increases in skeletal muscle mass and contractile function during development, and their maintenance d…
2026-09-10 · DOI: 10.64898/2026.09.06.749722 · 阅读原文 →
Manifestation of van der Waals interactions in the vibrational spectra of alkali metal dimers.
范德华相互作用在碱金属二聚体振动光谱中的体现
Gleb S. Denisov
This article is devoted to the analysis of the vibrational frequencies of alkali metal dimers from Li2 to Cs2 in the ground electronic state X 1Σ+ g, with the aim of identifying manifestation of van der Waals interaction…
2026-09-10 · DOI: 10.26434/chemrxiv.15008633/v1 · 阅读原文 →
Cfap410a and Cby work together with tissue-specific requirements to build Drosophila ciliary transition zones
Cfap410a与Cby协同作用并通过组织特异性需求构建果蝇纤毛过渡区
Amélie Billon, Jennifer Vieillard, Pranjali Priya, Minita Desai 等
Cilia and flagella perform essential physiological functions in eukaryotes, and defects in these organelles cause several human diseases, including cancer and ciliopathies. The architecture of cilia is highly organized. …
2026-09-10 · DOI: 10.64898/2026.09.08.749861 · 阅读原文 →
Expanded Access use of Intravenous Gene Transfer with AAV9-GLB1 in a Juvenile GM1 Gangliosidosis Participant
在青少年GM1神经节苷脂贮积症受试者中扩展使用AAV9-GLB1静脉基因转移
Connor Lewis, Hera Akmal, Precilla D'Souza, Jean M. Johnston 等
GM1 gangliosidosis is an inherited, progressively neurodegenerative lysosomal storage disorder with no approved therapy. We report 5-year safety and 3-year clinical, biochemical, and neuroimaging efficacy outcomes follow…
2026-09-10 · DOI: 10.64898/2026.09.04.26361573 · 阅读原文 →
PPARδ Expression and Prognosis in Resected Pancreatic Cancer: A Retrospective Single-Centre Study
PPARδ表达与切除胰腺癌的预后：一项回顾性单中心研究
Douglas Adamson, Shaun V Walsh, Iain S. Tait, Colin Neil Alexander Palmer
Background: Pancreatic cancer remains one of the most lethal malignancies, with limited curative options and poor long-term outcomes. Nuclear receptors, including PPARδ, have been implicated in tumour progression. Method…
2026-09-10 · DOI: 10.64898/2026.09.08.750098 · 阅读原文 →
From flagellar motor behavior to bacterial swimming: defining a reference state for motility dynamics in Magnetospirillum gryphiswaldense
从鞭毛马达行为到细菌游动：定义 Magnetospirillum gryphiswaldense 运动动力学的参考状态
Diego Rodolfo Roesch Martinez, Gabriel Delabre, Emilie Gachon
Cell motility is powered by the bacterial flagellar motor, a rotary nanomachine whose activity is dynamically modulated by external stimuli. In Magnetospirillum gryphiswaldense , magnetic and chemical inputs are thought …
2026-09-10 · DOI: 10.64898/2026.09.09.750318 · 阅读原文 →
GSDMD transcript levels are higher in endothelial than cardiomyocyte compartments across three human heart cohorts
GSDMD转录本水平在内皮细胞区室中高于心肌细胞区室：基于三个人心脏队列的研究
Daisuke Oryoji, Goro Doi, Sho Fujimoto, Naoya Nishimura 等
Cardiac GSDMD research has largely centred on cardiomyocytes. We quantified donor-level endothelial-minus-cardiomyocyte differences in two single-nucleus cohorts and one GeoMx spatial cohort, retaining assay-specific sca…
2026-09-10 · DOI: 10.64898/2026.09.06.749635 · 阅读原文 →
Neuronal and vascular genome-maintenance states organize opposing multicellular architectures in the aging brain
神经元与血管基因组维护状态在衰老大脑中组织对立的多细胞结构
Arvin Koshboresh, Vijay Laxmi Roy, Mofida Abdelmageed, Steffy B. Manjila 等
Genome maintenance is usually treated as cell-intrinsic, yet brain cells age within multicellular neighborhoods. Whether a cell's DNA damage response (DDR) state is systematically embedded in native tissue architecture i…
2026-09-10 · DOI: 10.64898/2026.09.07.749801 · 阅读原文 →
Computational Phenotypes for Temporomandibular and Orofacial Pain Disorders
颞下颌关节及口面部疼痛障碍的计算表型
Glenn Thomas Clark, Anette P Vistoso Monreal, Nicolas Veas Yanez, Gerald E. Loeb 等
Background: Temporomandibular disorders (TMDs) and orofacial pain (OFP) conditions affect approximately one-third of the global population, yet diagnosis often relies on subjective clinical assessment rather than standar…
2026-09-10 · DOI: 10.64898/2026.09.04.26351324 · 阅读原文 →
MUC5B and MUC5AC function in combination to regulate mucociliary transport on human airway epithelium
MUC5B与MUC5AC协同调控人气道上皮黏液纤毛运输
Sahana Kumar, Allison Boboltz, Gregg Duncan
Muco-obstructive lung diseases are characterized by impaired airway clearance and altered mucin composition. MUC5B and MUC5AC are the primary gel-forming mucins in airway mucus, yet how their relative abundance influence…
2026-09-10 · DOI: 10.64898/2026.09.08.750178 · 阅读原文 →
Cardiac Arrhythmia Associated with Psychoactive Drugs: An analysis of the FDA Adverse Event Reporting System
精神活性药物相关的心律失常：FDA不良事件报告系统分析
Mori Krantz, Mark C. Haigney, Mary Ross Southworth, Norman Stockbridge 等
Background: Several Schedule I substances have demonstrated potential benefits for refractory psychiatric conditions and addiction. Some have been legalized at the state level, while others like kratom (mitragynine) are …
2026-09-10 · DOI: 10.64898/2026.09.08.26362577 · 阅读原文 →
Concanavalin A as a pan-eukaryotic nuclear envelope marker for expansion microscopy
伴刀豆球蛋白A作为用于膨胀显微镜的泛真核核膜标记物
Baukje Hoogenberg, Felix Mikus, Priyesh Singh Parihar, IVA VERBANAC 等
Across eukaryotes, the nuclear envelope exhibits distinct remodelling strategies during mitosis: complete breakdown (open mitosis), partial disruption (intermediate), or full retention (closed). However, both light and e…
2026-09-10 · DOI: 10.64898/2026.09.08.750128 · 阅读原文 →